MBI111 Exam 3 Notes

MBI111 Exam 3 Notes - MBI111 Exam 3 Notes 10/12/2007...

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MBI111 Exam 3 Notes 12/10/2007 15:00:00 o Streptococcal diseases - upper respiratory tract (nasal, oral, throat cavity) o Streptococcus- encapsulated, gram +, chain forming o Classification- Hemolytic pattern: (red blood cell destruction) o Beta- clear zone due to complete destruction o Alpha- green zone on blood agar due to incomplete hemolysis o Gamma- no hemolysis Lancefield classification- based on variants of carbohydrate in cell wall o A-O o Most disease by group A strep- S. pyogenes is most common, aka  Group A beta-hemolytic strep o Group A strep (GAS) Streptococcus pyogenes 10-20% carrier rate Pharyngitis (strep throat) o A primary disease in pharynx o Transmission- droplets o Incubation- 1-3 days o Symptoms- high fever, swollen lymph nodes/tonsils, bright red pharynx  tissue
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M protein (in Streptococcus pyogenes)- in cell wall and pili, enhances  attachment and inhibits phagocytosis (adhesin/evasin), 60 antigenic types,  makes vaccine development difficult Scarlet fever- Group A strep plus toxin o Strep throat along with a skin rash (pink red blush on neck, chest, part  of arms, strawberry tongue) o Due to erythrogenic toxin Capillary wall damage- blood leaking Toxin only produced by certain strains Antibody to toxin provides immunity to scarlet fever rash (not  strep throat) Immune complications of GAS (1-4 weeks after acute infection) o Rheumatic fever- characterized by fever, inflammation of small blood  vessels, joint pain, permanent scarring of heart valves. Valves- Ab  specific to strep Ag cross reacts with heart tissue Glomerulonephritis- inflammation in kidney, can cause permanent  kidney damage
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MBI111 Notes 12/10/2007 15:00:00 o Influenza Symptoms: sudden chills, prodromal symptoms, fatigue, headache, pains in  chest, back and legs, fever rises to 104, severe cough develops, obstructed  nose, dry throat, tight chest (viral invasion of trachea and bronchi), stomach  flu is a misnomer (there is no flu of the stomach) Prognosis: favorable, normally short-lived, self-limiting, 7-10 days (immune  system response), can lead to secondary infections Diagnosis- symptoms and pattern of spread in community Treatment- Amantadine (interferes with attachment and uncoating), Tamiflu,  Relenza (last two target the neuraminidase) Vaccine (Inactivated virus)- can protect high-risk population, based on  predicted strain outbreak for each flu season Complications o Guillain-Barré syndrome Follows recovery or immunization Autoimmune attack on nerves, nerve damage, paralysis,  coma o Reye’s Syndrome (in children during recovery from flu of chickenpox) Rising fever, repeated protracted vomiting
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This note was uploaded on 04/07/2008 for the course MBI 111 taught by Professor Clark during the Spring '07 term at Miami University.

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MBI111 Exam 3 Notes - MBI111 Exam 3 Notes 10/12/2007...

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