Immune.08 - 0 NOTE! These files are provided for the sole...

Info iconThis preview shows pages 1–11. Sign up to view the full content.

View Full Document Right Arrow Icon
0 NOTE!! These files are provided for the sole purpose of assisting BSci 110 students to study for exams in the class. Some of the material in these files may be copyrighted, and it is not OK for you to share these files with anyone who is not a student in this class or to use them for any purpose other than to study for the exams of our class. Thanks, Carl Johnson
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Defenses Against Disease; The Immune System The enemies : Pathogenic bacteria (& their toxins) Pathogenic viruses Virus-infected cells Cancerous cells Non-specific defenses : 1. Barriers 2. Complement Proteins 3. Phagocytes et al 4. Inflammatory Response Specific defenses : the immune system 1
Background image of page 2
Defenses Against Disease Barriers: Skin Purves Table 18.1 What about burn victims? 2
Background image of page 3

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Defenses Against Disease Barriers: mucus Mucus in: 1. Respiratory tract (also nostril hairs) 2. Digestive tract 3. Saliva 4. Tears Lysozyme (lysing enzyme) Purves Table 18.1 3
Background image of page 4
Defenses Against Disease But, stuff gets past the barriers. What happens then? cuts, punctures inhalation, ingestion 4
Background image of page 5

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Defenses Against Disease Non-specific defenses: Complement Proteins : ~ 20 antimicrobial complement proteins in vertebrates. Complement proteins provide three types of defenses: 1.They attach to microbes, helping phagocytes recognize and destroy them. 2.They activate the inflammation response and attract phagocytes to the site of infection. 3.They lyse invading cells. Purves Table 18.1 Fever: next lecture! 5
Background image of page 6
Defenses Against Disease Non-specific defenses: Phagocytes engulf and digest foreign materials, especially pathogens or infected cells. There are several types, esp.: Neutrophils attack pathogens in infected tissue. Monocytes mature into macrophages . Mast cells release histamine when damaged and are important in allergies and the inflammation response. Purves 18.2 6
Background image of page 7

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Defenses Against Disease Non-specific defenses: Macrophages live longer and consume larger numbers of pathogens than do neutrophils. Some roam and others are stationary in lymph nodes and lymphoid tissue. 7 ingested bacteria C&R 43.4
Background image of page 8
Defenses Against Disease Non-specific defenses: The inflammation response tissue damage. Purves 18.4 The macrophages engulf invaders and debris and are responsible for most of the healing. They produce several cytokines, which may signal the brain to produce a fever. Pus , composed of dead cells and leaked fluid, may accumulate. 9
Background image of page 9

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
Which brings us to specific defenses: the Immune System! Recognition of “self” vs. “non-self” is mostly based on cell-surface proteins (usually glycoproteins; a "molecular fingerprint"); see MHC proteins below: Four groups of proteins play key roles in defending against disease: 1. Antibodies , secreted by B cells, bind specifically to certain substances (not the same as antibiotics!). 2. T cell receptors are cell surface receptors that bind non-self substances on the surface of other cells.
Background image of page 10
Image of page 11
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/07/2008 for the course BSCI 110B taught by Professor Due during the Spring '08 term at Vanderbilt.

Page1 / 39

Immune.08 - 0 NOTE! These files are provided for the sole...

This preview shows document pages 1 - 11. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online