P221_2004_Exam 2

P221_2004_Exam 2 - Pharmacy 221 Exam 2 Name Dr Langner Pick...

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Pharmacy 221 11/1/2004 Exam 2 Name:_____________________________________ Dr. Langner Pick the best answer for each question. 1. Which of the following statements best describes the mechanism of action of Ticlopodine? A. Inhibition of ADP binding to platelets B. Stimulation of platelet adenylate cyclase C. Inhibition of platelet phosphodiesterase activity D. It binds to activated platelet GPIIb/IIIa receptors E. None of the above 2. When platelets come in contact with collagen they release which of the following? A. Serotonin B. Thrombin C. Plasmin D. A & B are correct E. A, B and C are correct 3. Which of the following statements accurately describe protein C? A. Once protein C is activated it is rapidly inactivated by binding to platelet factor 4 B. Activation of protein C requires the presence of factor II a (thrombin) C. Activated protein C when complexed to protein S accelerates the rate of clotting factor activation which results in an acceleration in the rate of blood clot formation D. A and B are correct E. A , B and C are correct 4. Which of the following drugs has as its pharmacological mechanism of action inhibition of thrombin (Factor II a )? A. Enoxiparin B. Tirofiban C. Streptokinase D. Argatroban E. Anagrelide
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5. Which of the following agents must activate prekallikrein to kallikrein in order to breakdown fibrin? A. Tissue plasminogen activator (TPA) B. Urokinase C. Streptokinase D. Factor XIIa E. None of the above 6. Which of the following agents increases the activity of antithrombin III? A. Heparin B. Fondaparinux C. Anagrelide D. A and B are correct E. A, B and C are correct 7. Which of the following statements correctly describes the coumarin anticoagulants A. Coumarin anticoagulants inhibit the enzyme Vitamin K epoxide reductase B. Prolonged administration of coumarin anticoagulants may cause a reduction in protein C. C. Eating a diet high in Vitamin K may potentiate the anticoagulant effects of coumarin resulting in hemorrhaging. D.
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This note was uploaded on 04/07/2008 for the course PHRM 221 taught by Professor Langer during the Fall '04 term at UConn.

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P221_2004_Exam 2 - Pharmacy 221 Exam 2 Name Dr Langner Pick...

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