2003exam1 - Biochemistry 441 The exam has 5 pages. Hour...

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1 Biochemistry 441 Hour Exam 1 January 24, 2003 The exam has 5 pages. Name:_________________________________________ 1 /13 2 /22 Student number:_________________________________ 3 /26 4 /26 5 /13 Circle the letter by the single best answer. total /100 1. (4 points) Regulation of fatty acid biosynthesis occurs primarily at: A. formation of acetyl-CoA from acetate. B. the reaction catalyzed by acetyl-CoA carboxylase. C. condensation of acetyl-CoA and malonyl-CoA. D. reduction of the acetoacetyl group to a β -hydroxybutyryl group. E. formation of malonyl-CoA from malonate and coenzyme A. 2. (4 points) Which of these can be synthesized by plants but not by humans? A. palmitic acid (18:0). B. oleic acid (18:1). C. linoleic acid (18:2). D. mevalonic acid. E. lanosterol. 3. (5 points) In its monomeric form, the human fatty acid synthase will catalyze each of the individual steps in the synthesis of palmitic acid from acetyl-CoA and malonyl-CoA. Yet the monomeric enzyme can not catalyze the overall process. Explain the likely structural basis for these observations.
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2 4. (4 points) Which of the following statements about the synthesis of 1 mol of isopentenyl pyrophosphate from acetyl-CoA is not true? A.
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2003exam1 - Biochemistry 441 The exam has 5 pages. Hour...

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