2004exam3 - 1. (8 pts.) You are studying an enzyme that...

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1. (8 pts.) You are studying an enzyme that catalyzes the following reactions: ( a ) ACP-S-CO-CH 2 -CO-CH 3 + NADPH ACP-S-CO-CH 2 -CHOH-CH 3 + NADP + ( b ) ACP-S-CO-CH 2 -CHOH-CH 3 ACP-S-CO-CH=CH-CH 3 + H 2 O ( c ) ACP-S-CO-CH=CH-CH 3 + NADPH ACP-S-CO-CH 2 -CH 2 -CH 3 + NADP + ( d ) ACP-S-CO-CH 2 -CO-CH 3 + 2 NADPH ACP-S-CO-CH 2 -CH 2 -CH 3 + H 2 O + 2 NADP + You discover a mutant form of the enzyme that catalyzes reaction a , b or c as rapidly as the wild-type enzyme, but does not catalyze reaction d . What interpretion of this discovery would you suggest? 2. (10 pts.) The enzyme adenosine deaminase plays an important role in the catabolism of adenosine and deoxyadenosine to uric acid. Explain why a deficiency of this enzyme results in impaired synthesis of DNA.
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3. (6 pts.) Patients with Parkinson’s disease often are treated with a combination of dihydroxyphenylalanine (DOPA) and an inhibitor of catechol-O-methyltransferase (COMT). Why would a COMT inhibitor be helpful for these patients?
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This test prep was uploaded on 04/07/2008 for the course BIOC 441 taught by Professor Young&parson during the Winter '08 term at University of Washington.

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2004exam3 - 1. (8 pts.) You are studying an enzyme that...

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