CMB_Unit5_1.pdf - CELL-CELL ADHESION HOW TISSUES ARE FORMED...

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CELL-CELL ADHESIONHOW TISSUES ARE FORMED
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FIGURE 6-2 Major families of cell-adhesion molecules CAMs) and adhesion receptors. Dimeric E-cadherins mostcommonly form homophilic (self) cross-bridges with E-cadherins on adjacent cells. Members of the immunoglobulin (Ig) superfamily of CAMs can form both homophilic linkages (shown here) and heterophilic (nonself) linkages. Selectins, shown as dimers, contain a carbohydrate-binding lectin domain thatrecognizes specialized sugar structures on glycoproteins (shown here) and glycolipids on adjacent cells. Heterodimeric integrins(for example, v and 3 chains) function as CAMs or as adhesion receptors (shown here) that bind to very large, multiadhesivematrix proteins such as fibronectin, only a small part of which is shown here (see also Figure 6-25). Note that CAMs often formhigher-order oligomers within the plane of the plasma membrane. Many adhesive molecules contain multiple distinct domains,some of which are found in more than one kind of CAM. The cytoplasmic domains of these proteins are often associated withadapter proteins that link them to the cytoskeleton or to signaling pathways. [See R. O. Hynes, 1999, Trends Cell Biol. 9(12):M33, and R. O. Hynes, 2002, Cell110:673687.]
FIGURE 6-5 The principal types of cell junctions that connect the columnar epithelial cells lining the smallintestine. (a) Schematic cutaway drawing of intestinal epithelial cells. The basal surface of the cells rests on a basal lamina, and the apical surface is packed with fingerlike microvilli that project into the intestinal lumen. Tight junctions, lying just under the microvilli, prevent the diffusion of many substances between the intestinal lumen and the blood through the

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Term
Spring
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Trends Cell Biol, R O Hynes

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