genome organization

genome organization - attached to scaffold protein...

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Use TW and Purves to study the Outline on Genome Organization that is added to your Exam 2 Review.
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Today’s Topics Eukaryotic chromatin structure Eukaryotic Genome Organization
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Table 14.1 A Comparison of Prokaryotic and Eukaryotic Genes and Genomes
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(ACTIVE) (Inactive) Ponder this! Humans have 46 chromosomes Each uncoiled chromosome = 4-6 cm long (60,000 μm) Nucleus ~ 5 μm Several chromosomes and active site of ribosome synthesis
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Higher levels of DNA packing Double helix 2nm width Nucleosomes DNA around 8 histones 30 nm fiber nucleosomes coiled together Looped domain folded 30 nm fiber
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Unformatted text preview: attached to scaffold protein chromosome folding of looped domains Histones Main structural protein of chromatin. Arg and Lys rich (+) 2 each of 4 subunits => nucleosomes: H2A, H2B, H3 and H4. 2 turns (83 base pairs per turn) per nucleosome. H1 is the linker that pulls nucleosomes together. Allows access to the DNA The Eukaryotic Genome Organization Coding vs Noncoding Repeat Regions Highly repetitive Moderately repetitive Gene amplification Read the OUTLINE posted on the Blackboard....
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genome organization - attached to scaffold protein...

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