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Lecture22-2007 - Fates of Glucose-6P Glucose Pentose...

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1 Pentose Phosphate Pathway Lecture 22 Chapter 14, Section 6 Fates of Glucose-6P Glucose Glucose-6P Fructose-6P Fructose-1,6-BP Pentose-P Glycogen Pentose Phosphate Pathway Also called Pentose Phosphate Shunt, hexose monophosphate pathway, phosphogluconate pathway. • Purposes: to generate pentose-phosphates ( e.g. Ribose-5P) for nucleotides, cofactors, for dividing cells. To generate NADPH for biosynthetic reactions (e.g. fatty acid or cholesterol synthesis), mainly in liver, adipose, mammary gland, adrenal cortex. NADPH provides e - (reducing power) for biosynthetic reactions Allows for two pools of e - carriers in the same cellular compartment (cytosol) but for different purposes (catabolic) (anabolic)
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2 Three Stages Stage 1: Oxidative reactions, yielding 2 NADPH and one pentose-5P. Stage 2: Isomerization and epimerization, interconverting pentose-Ps. Stage 3: Non-oxidative reactions: rearrangements to convert three pentose-P (15C) to two fructose-6P and GAP (15C). Note: cells can do one or all stages depending on needs. Stage 1 Stage 2 Stage 3 Stage 1 Reaction 1: Glucose-6P dehydrogenase Irreversible reaction in cells Committed step in oxidative portion.
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