Lecture35-2007 - Fatty Acid Breakdown II Lecture 35 Chapter...

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1 Fatty Acid Breakdown II Lecture 35 Chapter 19-2 and 3 ß-oxidation of saturated Fatty Acyl- CoA with even numbers of carbons: ß-oxidation of unsaturated fatty acids requires extra steps: Two cases: 1. Unsaturation at odd number. 2. Unsaturation at even number. (18:1 ! 9) (18:2 ! 9 ! 12)
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2 (1st step of ß-oxidation) (odd number unsaturation) (not a substrate for AD) 14:2 ! 5 ! 8 18:2 ! 9 ! 12 12:2 ! 3 ! 6 (not a substrate for AD) 3,2- Note: lose FADH 2 b/c no AD (not a substrate for EH) (even number unsaturation) 12:2 ! 3 ! 6 10:2 ! 2 ! 4 (1st step of ß-oxidation) ~20% goes this direction due to 3,5-conjuated double bonds (not a substrate for EH) 14:2 ! 5 ! 8 18:2 ! 9 ! 12
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3 2,8-dienoyl-CoA ß-oxidation of odd chain fatty acids: SCoA SCoA Proprionyl-CoA (not a substrate for AD) 15:0 6 rounds of ß-oxidation Biotin Vitamin B12
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4 Vitamin B12 (5’-deoxyadenosylcobalamin) Forms a C-Co bond, allows formation of C radical (homolytic cleavage of bond) 5,6-dimethylbenzimidazole (DMB) 5’-Deoxy- adenosine Histidine in active site of mutase displaces DMB: Proposed mechanism for methyl-malonyl-CoA mutase Methylmalonyl-CoA Cytosol Matrix Malate Pyruvate Malic Enzyme
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This note was uploaded on 04/09/2008 for the course BIOCHEMIST 361 taught by Professor Haltiwanger during the Fall '08 term at SUNY Stony Brook.

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Lecture35-2007 - Fatty Acid Breakdown II Lecture 35 Chapter...

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