Pharm 2 CH 28 Summary.docx - Pharmacology 2 Chapter...

Pharmacology 2
Chapter Summary: Ch 28 Diuretic Drugs
Definitions & Concepts:
Diuretics: drugs that accelerate the rate of urine formation. The result is the removal of sodium &
water from the body.
Anuria- failure of kidneys to produce urine
Classified according to sites of action within the nephron, their chemical structure, and diuretic
potency. Increase Ca+.
RX raise uric acid level and CBG
OD- hypokalemia = muscle weakness, lethargy, mental confusion.
MEDS:
Classes: Carbonic Anhydrase Inhibitors: - not for DM increases glycosuria and CBG
Drugs: Diamox
Route:
Indication: adjunct in long term management of open angle glaucoma not controlled with drops.
May also be used to manage secondary edema with CHF when body is resistant to other meds.
Loop Diuretics :
Drugs: Lasix (furosemide)
Route: PO, IV or IM
MOA: work in the Loop of Henle blocking chloride and secondarily Na+ reabsorption. Rapid
onset of action and used when rapid diuresis is required.
Indicated: Edema secondary to CHF, liver or kidney disease, and to manage HTN
SE: Hypokalemia. Patients require monitoring of K+ level and may need replacement. SJS has