Campbell cell signaling

Campbell cell signaling - Cell communication and cell...

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1 Cell communication and cell signaling (“Signal transduction”) •Overview of cell signaling •Signal transduction pathways •Signal reception and initiation of transduction •Cellular responses •Refinement of the response Functions of cell signaling Growth <---> Cell division Identity <---> Cell fate specification Physiology <---> Cell metabolism Death <---> Apoptosis (programmed cell death) nucleus ER/organelle plasma membrane cytoplasm cytoskeleton INFO INFO INFO Cell signaling involves the transfer of information from the outside of the cell (extracellular compartment) to the inside of the cell (intracellular compartment) Most signal information must be transferred across membrane Only some signal information can pass through membranes unaided info must di ! use across a membrane, selective so needs help
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2 Cell signaling provides information in biological systems Information crosses barriers (plasma membrane, nuclear membrane, organelle membrane) Information travels distances (hormones) Information is relayed based on intermolecular interactions (e.g., small ligand-protein interactions, protein-protein interactions) Types of cell signaling Intercellular signaling Paracrine signaling Juxtacrine signaling Direct contact signaling Hormonal signaling Synaptic signaling proteins when they contact causes the relay of a process
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3 Intercellular signaling between yeast cells Signal-sending cells secrete ligand molecules (mating factors) to provide information for other cells Peptide “mating factors” bind to cell surface receptors on signal- receiving cells Information transduced by ligand-bound receptors causes cells to fuse with one another Paracrine signaling A signal-sending cell secretes ligand molecules (e.g., growth factors) Ligand molecules bind to receptors on the surfaces of target cells nearby Bound receptors provide information to signal- receiving cells Juxtacrine signaling (nearby signaling) [cell-cell recognition] Ligands that accumulate on the surfaces of signal-sending cells bind to receptors on the surfaces of signal-receiving cells Occurs among groups of developing cells and among immune system cells lots of cells near eachother but do not touch
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4 Direct contact signaling (cytoplasmic contact) Small signaling molecules (ligands) can travel between the cytoplasms of cells joined by gap junctions (animal cells) or plasmodesmata (plants) Hormonal signaling Ligands are produced in signal-sending endocrine cells and travel through the bloodstream to their
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Campbell cell signaling - Cell communication and cell...

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