Lecture #24 - Lecture 24 Metabolic Regulation Enzyme...

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10/25/2007 1 Lecture 24 Metabolic Regulation: Enzyme Activity and Synthesis Operons and Regulons BBOM 11e Sec. 8.1-8.7 Gene Regulation - Overview Fig 8.1.
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10/25/2007 2 “Enzyme Repression” “Enzyme Induction” 10 9 Protein concentration Per ml of lt Gene Regulation - terminology NOTE: The terms “Enzyme Induction” and “Enzyme Repression” DO NOT describe a molecular mechanism 10 7 10 8 culture Enzyme Repression could be due to a stimulus that: Activates a Transcriptional Repressor Protein, or Inactivates a Transcriptional Activator Protein Enzyme Induction could be due to a stimulus that: Inactivates a Transcriptional Repressor Protein, or Activates a Transcriptional Activator Protein Example: Enzyme Induction by Lactose (milk sugar) Mediated by a REPRESSOR protein and an INDUCER
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10/25/2007 3 DNA binding proteins general bind DNA as dimers or tetramers. Both the operator DNA and the DNA binding protein show: “Rotational Symmetry” or “Dyad Symmetry” Example: Enzyme Repression by the amino acid Arginine Mediated by a REPRESSOR (ArgR) and a COREPRESSOR (arginine)
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