Lecture #22 - BioMI 290, Fall 2007, Lecture 22 1 Lecture 22...

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Unformatted text preview: BioMI 290, Fall 2007, Lecture 22 1 Lecture 22 Lecture 22 Transcription (Synthesis of RNA using a DNA template) Transcription (Synthesis of RNA using a DNA template) BBOM 11e Sec. 7.8 - 7.13 How is the information stored in DNA retrieved and expressed? The Central Dogma: Replication of DNA creates more DNA Transcription of DNA creates mRNA, rRNA, and tRNA Translation of mRNA creates proteins BioMI 290, Fall 2007, Lecture 22 2 RNA Structure : BBOM 11e Sec. 3.5 1. RNA has the same basic components as DNA with two major exceptions a. Uracil replaces Thymine b. Ribose replaces Deoxyribose RNA Structure and Function RNA Structure and Function DNA RNA uracil OH Other differences: RNA is shorter: 100-10,000 nucleotides vs. millions of nucleotides RNA usually is single-stranded and can adopt complex shapes Many RNAs are unstable and are degraded within minutes. RNA OH OH RNA Polymerase (RNAP) Like DNA polymerase (5=>3) synthesis RNA Polymerase (RNAP) Like DNA polymerase (5=>3) synthesis OH RNA polymerase (RNAP) Ribose OH OH ALL nucleic acid polymerases can ONLY act in one direction, 5 3 (because they all use 5-triphosphates as a substrate for synthesis). Ribose Ribose BioMI 290, Fall 2007, Lecture 22 3 , , 2 Transcription - Initiation at PROMOTER sites Note: DNA strands Are written 5 to 3 Region melted By RNAP at Initiation Sigma recognizes the promoter and converts it to a single-stranded form....
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This note was uploaded on 02/13/2008 for the course BIO 2900 taught by Professor Ghiorse during the Fall '07 term at Cornell University (Engineering School).

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Lecture #22 - BioMI 290, Fall 2007, Lecture 22 1 Lecture 22...

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