Ch06_LO - CH369:LearningOutcomes Chapter6 61 o o o o

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CH 369: Learning Outcomes Chapter 6 6-1: Know the basic principles behind the function of enzymes as biological catalysts o Not permanently altered or consumed o Active site is where substrate binds and catalysis takes place o How they differ from metal catalysts o Function by lowering the activation energy ( E a  or D G ) and thereby speeding up  reaction (lower the energy of the transition state) o Do NOT change equilibrium of reaction o Provide alternate reaction pathway Know the enzyme classifications and be able to determine the enzyme classification from the reaction it catalyzes 6-2: Know the difference between the D G  of the reaction and the D G  of the transition state Understand the concept of the transition step in a chemical reaction o Intermediate between substrates and products o The higher the energy of the transition state – the higher the energy hill – the 
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