Ch14_LO - CH369:LearningOutcomes Chapter14 141...

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CH 369: Learning Outcomes Chapter 14 14-1: Know why the TCA cycle is a central pathway and how it is amphibolic Transition step o Know the net reaction o Know where this takes place in the cell o Know the organization of the pyruvate dehydrogenase complex What is the order of the enzymes within the complex? Be able to recognize the structures of its cofactors and which enzyme each is  associated with These enzymes can simply be remembered as E1, E2, and E3 – but make sure  you know which of these is pyruvate dehydrogenase Know how these cofactors participate in the conversion of pyruvate to acetyl- CoA Know the general benefits of a multi-enzyme complex 14-2: TCA cycle o Know the net reaction o Know the structure of oxaloacetate and that it is the substrate of the first step and  regenerated in the last o
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