Lecture 12 - Wednesday Lecture 12 Announcements 1 The...

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Wednesday, September 20, 2006 Lecture 12 Announcements 1. The RasMol exercise for this week is #5: Hemoglobin. The originally-scheduled Tour of the Protein Data Bank, Rasmol #4, will be assigned next week. But some Hb scripts are not working on some PCs at this time. We are working on this problem… 2. Prof. Feigenson will meet with any 331 students who would like to discuss “Applying to medical school, the role of the HCEC, and letters of recommendation", this Friday, 9/22 from 1:25 – 2:15PM in Comstock B106. Monday’s lecture: Being a TA in Qatar…. (Tadhg Begley) Protein classification by function, by complexity; Comparison of Mb and Hb structure; Introduction to the sigmoid curve; Today's lecture: Description of the O 2 binding curve: Mb + O 2 MbO 2 For Mb, the corresponding K eq is a large number. This means that MbO 2 is the predominant form at all physiological pO 2 . So we should re-write the above equation with the arrow toward the right much longer than the arrow toward the left.
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K eq(1st O 2 ) : the first oxygen molecule binds to Hb. K eq(2nd O 2 ) : the seconds oxygen molecule binds to Hb(O 2 ) K eq(3rd O 2 ) : the third oxygen molecule binds to Hb (O 2)2 . The K eq is larger. K eq(4th O 2 ) : the fourth oxygen molecule binds to Hb(O 2)3 . the K eq is again large. Keq(4th O 2 ) is ~ 300x larger than Keq(1st O 2 ) so this is a BIG effect!
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