Synthesis Of Aspirin Lab - Name Joseph Youkhanna CHM2230...

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Name: Joseph Youkhanna CHM2230 : Section 11 Title: Synthesis of Aspirin Date: March 21 st , 2007 Purpose: The purpose of this experiment is to synthesize 1.0g of Aspirin beginning with salicylic acid and acetic anhydride; these starting materials are very in expensive, and well known. This is a well-known esterification reaction using an anhydride and alcohol. Table of Reagents: Reagent Name Molecular Weight Mol used 1-2 g of salicylic acid 138.12 g/mol .0217 mol 3 mL of acetic anhydride 102.09 g/mol .0034 mol 5-8 drops of H2SO4 97.99 g/mol NA 50 mL of ice water 18.02 g/mol NA Product Data: Melting Point – 135ºC Percent Yield – was not provided in this lab Scheme for all Reactions: Mechanisms (Reaction Scheme):
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Procedure: 1. Accurately weigh 1-2 g of salicylic acid and transfer it to a dry Erlenmeyer flask (doesn’t matter what size) 2. Add 3 mL of acetic anhydride and 5-8 drops of H2SO4 3. Swirl the flask gently to mix, then place the flask in a beaker of warm water for about 10-15 minutes. 4. Run under cool water, and then add 25 mL of cold water. This destroys the excess acetic anhydride. 5. Then put the flask in an ice bath to cool the mixture and speed the crystallization of aspirin. 6. When the crystallization seems complete pour the entire mixture through a Buckner funnel. 7. Apply suction filtration through the funnel and wash the crystals with a few milliliters of ice cold water. 8. Now time for recrystallization (you do not have to recrystallize if the crystals from suction filtration are pure white according to our TA). Transfer the crystals to a beaker and add 10 mL of ethyl alcohol. Stir to dissolve, warming the beaker to speed the
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