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learning goals for lectures 31 and 32

learning goals for lectures 31 and 32 - Relationships among...

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Relationships among glycolytic path, pyruvate dehydrogenase, and kreb’s cycle Glycolysis yields 2 pyruvates pyruvate dehydrogenase complex (3 enzymes and 5 coenzymes) oxidizes pyruvate actetyl coenzymeA which enters kreb’s cycle Pyruvate dehydrogenase complex: the rxns it catalyxes and the role of each cofactor Enzyme 1 and TPP (thiamine pyrophosphate), TPP is attached to E1 and pyruvate binds to it and decarboxylates and it is left with a hydroxyl group. E2 and lipoate and CoA lipoate oxidizes the acetyl group so it is now a ketone. CoZ now attacks the acetyl group and it leaves as acetyl-CoA (high energy b/c thioester) and lipoate accepts more e-. on E3 FAD then oxidizes the lipoate back to regular form and FAD is now FADH2. FADH2 then passes its e- to NAD+ to form NADH and H+. So all the cofactors are TPP, lipoate, CoA, FAD, and NAD+ Know the structure and name of each intermediate of the kreb’s cycle and where each cofactor is involved Structures of the business ends of TPP, lipoic acid
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Intracellular localization of the kreb’s cycle enzymes Mitochondria contain all the enzymes and coenzymes required for the citric acid cycles Citric acid cycle takes place in the matrix Describe analogy between the α-ketoglutarate dehydrogenase reaction and the pyruvate dehydrogenase reaction Α-ketoglutarate dehydrogenase is same as PDH, E1 has bound TPP and bound lipoate E2 has bound lipoyl moieties, E3 is the exact same Only difference is that E1s have slightly different amino acid sequences so PDH
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