Summary_of_all_reactions

Summary_of_all_reactions - Gatterman-Koch formylation H 2...

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1 Alkenes CH 3 H H 3 C H 3 C HX markovnokov CH 3 H CH 3 H 3 C H X H CH 3 CH 3 H 3 C OH H HX/R-O-O-R Anti markovnokov CH 3 H CH 3 H 3 C H OH 1)Hg(OAc) 2 /H 2 O 2)NaBH 4 /OH - markovnokov CH 3 H CH 3 H 3 C X H Anti markovnokov BH 3 /THF H 2 O 2 /OH - H CH 3 CH 3 H 3 C H H H 2 /Pt X CH 3 CH 3 H 3 C H X CH 3 H H 3 C H 3 C X 2 /CCl 4 Ph O O O H O anti addition anti addition Syn addition Syn addition O CH 3 H O 3 /(CH 3 ) 2 S O CH 3 H O H 3 C H 3 C + KMnO 4 ,warm, conc O H 3 C H 3 C + O CH 3 OH O r O 3 /Zn/HCl H CH 3 CH 3 H 3 C OH OH OsO 4 /H 2 O 2 O r KMnO 4 /OH - X 2 /H 2 O OH CH 3 CH 3 H 3 C H X anti addition
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2 Alkynes H H 3 C HX markovnokov H H 3 C H X H H H 3 C O H HX/R-O-O-R Anti markovnokov H H H 3 C H O HgSO 4 /H 2 SO 4 H 2 O markovnokov H X H H 3 C X H Anti markovnokov BH 3 /THF H 2 O 2 /OH - H H H H 3 C H H H 2 /Pt X H 3 C H X 1 mole X 2 /CCl 4 anti addition Syn addition O OH H O 3 /(CH 3 ) 2 S KMnO 4 ,warm, conc/OH - O HO H 3 C + O r X 2 /CCl 4 X H X H 3 C X X H H X H 3 C H X H H 3 C H H H H 3 C H H M/NH3 M=Li, Na orK H 2 /Pd/BaSO 4 quinoline Or Lindlar Catalyst Syn addition of H 2 anti addition of H 2 HX X H 3 C H H H X / R - O 2 NaNH 2 /H 2 O 150 o C C - Na + H 3 C NaNH 2 /NH 3 CH 3 CH 2 X H 3 C SN2, works just with a primary
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3 Reaction of Aromatic compounds Br NO 2 SO 3 H C(CH 3 ) 3 O R O H SO 3 /H 2 SO 4 H 2 O, heat HNO 3 /H 2 SO 4 Br 2 /FeBr 3 R O Cl , AlCl 3 CO/HCl AlCl 3 /CuCl (CH 3 ) 3 C-Cl AlCl 3 O r (CH 3 ) 3 C-OH H 2 SO 4 O r (CH 3 ) 2 C=CH 2 HF Friedel-Craft alkylation Ketone Friedel-Craft acylation Benzaldehyde
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Unformatted text preview: Gatterman-Koch formylation H 2 /Ru 100 o C, 1000 psi Substituant affects Alkyls, -NH2, -NH-CO(R), -OR , -OH, -O- are electron donating groups are avtivators, ortho and para directors. Cl, Br, F, I, electron withdrawing group are deactivators but ortho and para directors. -NO2, -SO3H, -N + R3, acyl, -CN withdrawing group are deactivators, meta directors 4 ED EW ED EW M/NH 3 , ROH M=Li, Na or K Birch Reduction Side chain reactions KMnO 4 conc,hot H 2 O O OH oxydation O Br Cl Cl Cl Cl Cl Br 2 /h excess Cl 2 /h Zn/Hg HCl Clemmensen reduction Nu-Nu + Br-SN 2 or SN 1 (CH3)3CO-,Na + H 2 /Pd...
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Summary_of_all_reactions - Gatterman-Koch formylation H 2...

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