LECTURE 17 - Biology of Cancer and AIDS Lecture 17:...

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Lecture 17: Children Get Cancers Too! Biology of Cancer and AIDS
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Childhood Cancers Leading cause of disease-related death among children in the United States; afflicting ~12,400 children under the age of 15 annually Childhood cancers appear to be increasing at a rate of approximately 1% each year Increased rate most pronounced in leukemia and tumors of the central nervous system (CNS) Cancer is the most common disease-related cause of death for ages one to twenty, and the fourth most common cause of all deaths, after accidents, homicides, and suicides. Environmental Health Perspectives Volume 106, Number 1, January 1998
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Incidence/Prevalence Cancer in adults is fairly common (1 in 3 adults will develop some form of cancer) It is extremely rare for children to have cancer (1 in 600) Causation Approximately 90% of adult cancers can be attributed to environmental factors Most children with childhood cancer have no clear causation be it genetic or environmental Survivability Most striking difference or contrast between childhood cancer and adult cancer is childhood cancer is much more curable than adult cancer (2/3 children survive and live healthy lives) Adult survivability for cancer overall is much less than 50% http://www.dana-farber.org/abo/news/publications/pop/fall- winter-2000/aging.asp
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Possible Causes of Childhood Cancer The best established environmental cause of childhood cancer is ionizing radiation High dose radiation exposure linked to ALL, AML, osteosarcoma, thyroid cancer, and soft-tissue sarcoma Viral infections might be involved in certain non-Hodgkin's lymphomas & leukemia Maternal use of alcohol during pregnancy was associated with a more than two-fold increased risk of ALL (odds ratio = 2.6)
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http://www.acor.org/ped-onc/diseases/SOCC.html Signs of Childhood Cancer
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Incidence Nearly 30% of U.S. population is under the age of 20. In this age group: Approximately 12,400 are diagnosed with cancer each year.
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LECTURE 17 - Biology of Cancer and AIDS Lecture 17:...

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