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TCA cycle - the anaplerotic reactions To b oxidation...

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153 to fat to fat pyruvate to glucose AcCoA citrate synthase citrate oxaloacetate NADH aconitase isocitrate malate dehydrogenase fumarase succinate dehydrogenase malate fumarate α -ketoglutarate isocitrate dehydrogenase NADH NADH CoA α - KG dehydrogenase FADH 2 succinate GTP succinyl CoA succinate thiokinase Figure 12-1 The Tricarboxylic Acid (TCA) Cycle C H A P T E R 12 TCA CYCLE
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154 Basic Concepts in Biochemistry TCA CYCLE 1 (see Fig. 12-1.) Function: To burn the acetyl-CoA made from fat, glucose, or protein in order to make ATP in cooperation with oxidative phosphorylation. Location: All cells with mitochondria. Connections: From glycolysis through acetyl-CoA. Pyruvate makes oxaloacetate and malate through
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Unformatted text preview: the anaplerotic reactions. To b oxidation through acetyl-CoA. To amino acid degradation through acetyl-CoA and various intermediates of the cycle. Regulation: Supply and demand of TCA cycle. Availability of NAD 1 and FAD as substrates. Inhibition by NADH. High-energy signals turn off . Low-energy signals turn on . ATP yield: Pyruvate ¡ 15ATP Acetyl-CoA ¡ 12ATP Equations: Pyruvate 1 GDP 1 P i 1 3NAD 1 1 FAD ¡ 3CO 2 1 GTP 1 3NADH 1 FADH 2 1 3H 1 Acetyl-CoA 1 GDP 1 P i 1 2NAD 1 1 FAD ¡ 2CO 2 1 GTP 1 2NADH 1 FADH 2 1 2H 1 1 The tricarboxylic acid cycle is also known as the Krebs cycle or the citric acid cycle. Why give something so central to life only one name?...
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