L08-PsychopharmacologyII - Psychopharmacology Drug...

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February 15, 2007 Psychopharmacology Drug Withdrawal Effects o Drug exposure leads to the development of adaptive neural changes that produce tolerance by counteracting the drug effect o With no drug to counteract them, the neural adaptations produce withdrawal effects opposite to the effects of the drug Tolerance as a learned behavior o Contingent tolerance: drug tolerance that develops as a reaction to the experience of drug effects rather than to drug exposure alone. Alcohol and Seizures example o Conditioned Tolerance: Tolerance effects are maximally expressed when a drug is administered in the same situation in which it has previously been administered. Hypothermic response due to alcohol injections in different environments Neuropsychopharmacology o Therapeutic uses of drugs o Addictive properties of drugs o Effects on behavior o Effects on NT systems (What we are studying) Monoamines and “Good Times” o Many drugs that are associated with addiction affect the monoaminergic
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This note was uploaded on 04/09/2008 for the course PSYC 220 taught by Professor Brunges during the Spring '07 term at UVA.

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L08-PsychopharmacologyII - Psychopharmacology Drug...

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