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Unformatted text preview: February 20 , 2007 Neurotransmitter Receptors and Neuromodulators • Glutamate (Glu; Glutamic Acid) o Amino acid neurotransmitter o Most important excitatory NT in the brain o Produced in neurons by metabolism o No effective way to block synthesis without disrupting other cell activities; if you disrupt it, you will also block other essential functions in the cell. • Glutamate Receptors o Four major kinds (First 3 are all Ionotropic) NMDA AMPA Kainate Metabotropic glutamate receptor (mGluR) Iontropic receptors: Ion channel is the receptor o AMPA Stimulated by AMPA Most common Glu receptor Ionotropic; Na+ channel Excitatory o Kainate Stimulated by Kainic acid Ionotropic; Na+ channel o NMDA Activated by NMDA Ionotropic; permeable to Na+ and Ca2+ Includes 6 different binding sites • 4 on extracellular surface • 2 deep within ion channel o Magnesium and PCP block flow of ions and Mg2+ exists at the receptor during resting potential o When the neuron is depolarized, Magnesium leaves the NMDA receptor and Calcium/Sodium ions can flow freely Blocked by Mg2+ at rest but postsynaptic membrane depolarization unblocks Important for learning and memory • Dynamic Regulation of Synapses...
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- Spring '07
- Neurotransmitter, NMDA, NMDA receptor, AMPA receptors