Receptor_Kinetics1

Receptor_Kinetics1 - Chemical Rate Laws S K P dS (t ) = - K...

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Chemical Rate Laws K SP ⎯⎯⎯→ () , (0) , dS t KS t S dt dP t t P dt =− ⋅ =⋅
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Chemical Rate Laws 12 K SS P +⎯ 1 1 2 2 () , (0) , , dS t KSt S t S dt dS t S t S dt dP t S t P dt =− ⋅ =⋅
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Chemical Rate Laws 12 ... n K SS S P ++ + () (). . . , (0) , 1 , . . . , . . , i n i n dS t KSt S t S t S i n dt dP t S t S t P dt =− ⋅ ⋅ ⋅ = =⋅
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Chemical Rate Laws 2 K SP ⎯⎯⎯→ 2 2 () , (0) , dS t KS t S dt dP t t P dt =− ⋅ =⋅
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One Binding Site – One Conformational State 1 2 K K LR R L ⎯⎯→ ←⎯⎯ + 12 () () () , (0) , , dL t KL t R t K R L t L dt dR t t R t K R L t R dt dRL t t R t K R L t R L dt =− + + =⋅ Receptor – Ligand Interactions
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One Binding Site – Two Conformational States 3 1 24 12 K K KK L R RL ⎯⎯→ ←⎯⎯ + 3 4 34 () () () , (0) , 1( ) 1 1 2() , 1 2( ) 2( ), 2(0) dL t KL tR t K R L t L dt dR t t K R L t R dt dRL t K L t R t K RL t K RL t K RL t RL dt dRL t KR L t Lt R L dt =− + + = ⋅− ⋅+ =⋅ −⋅ Receptor – Ligand Interactions
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Enzyme Kinetics
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Receptor_Kinetics1 - Chemical Rate Laws S K P dS (t ) = - K...

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