Pentose Phosphate Pathway

Pentose Phosphate Pathway - C H A P T E R 15 PENTOSE...

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183 C H A P T E R 15 PENTOSE PHOSPHATE PATHWAY PENTOSE PHOSPHATE PATHWAY Function: To supply reducing equivalents for biosynthesis (NADPH) and pentoses for DNA and RNA bio- synthesis. Location: Everywhere. Connections: To glycolysis and glycogen through glucose 6-phos- phate . Shares some enzymes with glycolysis. To DNA-RNA synthesis through ribose 5-phosphate . Regulation: NADPH inhibits. NADP activates. High glucose 6-phosphate activates. EQUATIONS: Making NADPH: 3 Glucose 6-P 6NADP ¡ 2 fructose 6-P glyceraldehyde 3-P 3CO 2 6NADPH 6H Making ribose 5-P: Glucose 6-P 2NADP ¡ ribose 5-P CO 2 2NADPH 2H
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184 Basic Concepts in Biochemistry The hexose monophosphate pathway has several names just to con- fuse you. It’s called the hexose monophosphate shunt or pathway (HMP shunt or pathway), or the pentose phosphate pathway, or the phospho- gluconate pathway (Fig. 15-1). The pathway in its full form is compli- cated and has complicated stoichiometry. Usually it’s not necessary to
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