Purine Metabolism

Purine Metabolism - C H A P T E R 19 PURINE METABOLISM...

Info iconThis preview shows pages 1–3. Sign up to view the full content.

View Full Document Right Arrow Icon
227 C H A P T E R 19 PURINE METABOLISM Purine Synthesis Purine Salvage Deoxynucleotides Purine Degradation (See Fig. 19-1.) PURINE SYNTHESIS Function: To provide purines (A and G) for energy metabolism and for DNA-RNA synthesis. Location: Cytoplasm of most cells. Connections: To folate metabolism and one-carbon metabolism in de novo synthesis. From HMP pathway via ribose and PRPP. To deoxyribonucleotides through ribonucleotide reductase. Regulation: Availability of PRPP. Activity of the enzyme catalyzing the formation of the 5-phos- phoribosyl-1-amine from PRPP is inhibited by purines. Synthesis of GMP requires ATP. Synthesis of AMP requires GTP. Equation: PRPP 1 glutamine 1 glycine 1 formyl-THF 1 aspartate 1 some ATP ¡ purines
Background image of page 1

Info iconThis preview has intentionally blurred sections. Sign up to view the full version.

View Full DocumentRight Arrow Icon
228 Basic Concepts in Biochemistry The free bases of the purines can be salvaged to spare de novo syn- thesis. The only hard thing is remembering what the names stand for. HGPRTase is hypoxanthine-guanine phosphoribosyltransferase, and it
Background image of page 2
Image of page 3
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 04/09/2008 for the course BIO SCI 98 taught by Professor Goulding during the Spring '08 term at UC Irvine.

Page1 / 3

Purine Metabolism - C H A P T E R 19 PURINE METABOLISM...

This preview shows document pages 1 - 3. Sign up to view the full document.

View Full Document Right Arrow Icon
Ask a homework question - tutors are online