Pyrimidine Metabolism

Pyrimidine Metabolism - C H A P T E R 20 PYRIMIDINE...

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230 C H A P T E R 20 PYRIMIDINE METABOLISM Pyrimidine Synthesis Pyrimidine Salvage Pyrimidine Degradation The major difference between purine and pyrimidine de novo biosynthe- sis is that the pyrimidine ring is assembled and then added to PRPP (Fig. 20-1). With purines, the purine ring is built directly on the PRPP. PYRIMIDINE SYNTHESIS Function: To make pyrimidine nucleotides (U, T, C) for DNA and RNA synthesis. Location: Cytoplasm of most cells. Connections: To amino acid metabolism by the requirement for glutamine and aspartate. Regulation: UTP inhibits synthesis of carbamoylphosphate. Equation: Gln 1 CO 2 1 Asp 1 PRPP 1 some ATP ¡ UTP 1 CTP
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20 Pyrimidine Metabolism 231 There are basically two types of salvage. The first involves attach- ment of the base to PRPP with the formation of pyrophosphate. This pathway is available for salvage of purines and uracil but not for cyto- sine or thymine. The other pathway involves attachment of the base to
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This note was uploaded on 04/09/2008 for the course BIO SCI 98 taught by Professor Goulding during the Spring '08 term at UC Irvine.

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Pyrimidine Metabolism - C H A P T E R 20 PYRIMIDINE...

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