Urea Cycle - C H A P T E R 18 UREA CYCLE UREA CYCLE...

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225 C H A P T E R 18 UREA CYCLE (See Fig. 18-1.) UREA CYCLE Function: To provide a route to dispose of the amino groups from amino acids during their metabolism. Location: Liver, kidney Connections: From amino groups of amino acids through gluta- mate and glutamate dehydrogenase From amino groups of amino acids through aspartate and ar- gininosuccinate synthase From ammonia through carbamoyl phosphate synthetase To urea Regulation: Primarily by availability of amino groups and ammonia Equation: NH 1 4 1 CO 2 1 Asp 1 2ATP ¡ NH 2 C( O)NH 2 1 fumarate 1 2ADP 1 2P i Glu 1 NAD 1 1 CO 2 1 Asp 1 2ATP ¡ NH 2 C( O)NH 2 1a -ketoglutarate 1 fumarate 1 2ADP 1 2P i
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226 Basic Concepts in Biochemistry H 3 N ATP —— NH 2 NH CN H
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Urea Cycle - C H A P T E R 18 UREA CYCLE UREA CYCLE...

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