Hemostasis Disorders Abnormal Blood Clots: A clot that forms abnormally in a vessel is a thrombus . If the above clot dislodges, it is a(n) embolus . What is a coronary thrombosis? Coronary thrombosis is a blood clot inside a vein/artery that restricts blood flow to the heart What is hemophilia? Hemophilia refers to several bleeding disorders in which the blood cannot clot properly. Hemophilia A results from a lack of factor VIII and accounts for most of the cases. Hemophilia B results from a lack of fact IX. Hemophilia C results from a lack of factor XI. Hemophilias A & B occur primarily in males while Hemophilia C occurs in both sexes. Blood Groups and Transfusions: After mixed success with transfusions, scientists determined that blood was of different types and only certain combinations were compatible. Clumping of red blood cells following transfusion is called agglutination . This clumping is due to the interaction of proteins on the surfaces of red blood cells called antigens with certain proteins called agglutinins carried in the plasma. Blood Types: Define antigen and antibody- Antigen – An antigen is an RBC membrane with specific markers that are unique to each body. Anything the body perceives as foreign, it will generate an immune response. Antibody – The body’s chemical agent that attaches itself to the antigen and either cleans or kills the cell Identify the antigens and antibodies found in the following blood types. Table 17.4 on page 657 in the textbook will help you with this question. Blood Type Antigen Antibody A A B B B A AB AB None O None A, B RH Blood Types 6
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