Lectures 12 - 14 - Membranes

The protein acts as surrogate water k(oh 2 8 =

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Unformatted text preview: The protein acts as surrogate Water K (OH 2 ) 8 + = hydration shell (8 H 2 O needed to stabilize K + ) Within the K + Ion Channel only: Resolvation Energy ~ Desolvation Energy Na (OH 2 ) 6 + = hydration shell (6 H 2 O needed to stabilize Na + ) Within the K + Ion Channel only: Resolvation Energy <<< Desolvation Energy **When two K + occupy adjacent sites, electrostatic repulsion forces them apart. Thus, as a K + enters the selectivity filter from one side, repulsive force from the next K + entering the filter pushes the first ion through the pore and out the other side, namely out of the cell. The Synapse – The Converging Paradigm Of Neuroscience Ligand-gated channels Voltage-gated channels Stryer: Biochemistry, Third Ed. © 1988, W.H. Freeman & Co. Nature 440 :440-447 (2006) Hartshorne, et al. PNAS 82:240-244 (1985) Nelson, et al. PNAS 77:3057-3061 (1980) Modular Design of Eukaryotic Kv Channels S1 S2 S3 S4 S5 S6 + + + + + + + + P----- Voltage- Sensor Selective Pore A prokaryotic Kv channel with essential sequence conservation of the voltage sensor. Santos J S et al. J Gen Physiol 2006;128:283-292 The Rockefeller University Press Long & Mackinnon ubunit gating I- +...
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The protein acts as surrogate Water K(OH 2 8 = hydration...

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