Where youll see big oval macrophagesred cells liver

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Where you’ll see big oval macrophages/red cells Liver Disease If doing morphological classifications – can be mistaken for folate/B 12 deficiency but it may be liver disease Bone Marrow Failure (anemia) Avg. %age of cells in bone marrow 50 in adults (remaining 50 is fat) (Older people break hip---osteoblasts not working as well---fat emboli---dislodge fat in circulation---clot) Sternum, ribs, skull, hips (iliac crest), vertebrae – in adult In children most bones produce bone marrow – in leukemia – bones painful in children Osteoblasts (break down bone) Osteoclasts (make bone) Bone marrow failure would be considered <20% = aplastic anemia ---- get a pancytopenia (no precursor cells so can’t make more cells) So DNA and bone marrow problems----same appearance *Many mechanisms: Destruction of stem cells due to injury, drugs, chemical radiation, autoimmune viruses, pregnancy (pg. 260) vast majority is acquired (Important to know cause- if acquired – and you don’t know you’re exposed to a chemical, bone marrow will never recover)
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EXAM III MATERIAL Aplastic, Hypoplastic anemia Apoptosis / Disappearance of Cells Stem Cell Mutations Disruption of Micro Environment of Bone Marrow Deficiencies in B 12 and Folate Low production of Growth Factors (IL2, Erythropoeitins) Infiltration of Cancer Cells- i.e. metastasis of cancer (usually lungs/breast) (In some 4 Stage cancers, develop anemia) Box 21 -3 can see some of the drugs that are involved ---just glance at it Basically Quantitative/ Qualitative Deficiency of Hematopoietic Stem Cells Fig. pg. 263 Top 1 = normal marrow – white area = fat Bottom = hypoplastic – has aplastic anemia – Hg, HCT will be low to extremely low Aplastic Anemia Non-severe Severe Very Severe (not going to want to do a diff on an aplastic anemia patient) Go by the count ----lower you go----more severe
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