When dna is compacted by histones into 10 nm and 30

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55) When DNA is compacted by histones into 10 nm and 30 nm fibers, the DNA is unable to interact with proteins required for gene expression. Therefore, to allow for these proteins to act, the chromatin must constantly alter its structure. Which processes contribute to this dynamic activity? A) DNA supercoiling at or around H1 B) methylation and phosphorylation of histone tails C) hydrolysis of DNA molecules where they are wrapped around the nucleosome core D) accessibility of heterochromatin to phosphorylating enzymes E) nucleotide excision and reconstruction Answer: B Topic: Concept 16.3 Skill: Application/Analysis 56) About how many more genes are there in the haploid human genome than in a typical bacterial genome? 15
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57) In prophase I of meiosis in female Drosophila , studies have shown that there is phosphorylation of an amino acid in the tails of histones. A mutation in flies that interferes with this process results in sterility. Which of the following is the most likely hypothesis? 58) In a linear eukaryotic chromatin sample, which of the following strands is looped into domains by scaffolding? 59) Which of the following statements describes the eukaryotic chromosome? A) It is composed of DNA alone. B) The nucleosome is its most basic functional subunit. C) The number of genes on each chromosome is different in different cell types of an organism. D) It consists of a single linear molecule of double-stranded DNA. E) Active transcription occurs on heterochromatin. Answer: D Topic: Concept 16.3 Skill: Knowledge/Comprehension 60) If a cell were unable to produce histone proteins, which of the following would be a likely effect? 16
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