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Psy 103-Schizophrenia

G timothy crow nancy andreasen eg timothy crow nancy

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(e.g, Timothy Crow, Nancy Andreasen) (e.g, Timothy Crow, Nancy Andreasen) Forced us to look at schizophrenia in a new way. Composed of two major syndroms Positive-symptom schizophrenia ( Type I ) an exaggeration of normal behavior Hallucinations | Psychotic Delusions _|______________ Paranoid or silly affect | Disorganized Bizarre or disorganized behavior | Disordered thought processes | Negative-symptom schizophrenia ( Type II, Deficit Syndrome ) – deficits in normal behavior Flat affect Psychomotor retardation Mutism and blocking Poor grooming Social withdrawal Positive vs. Negative Symptom Schizophrenia Positive vs. Negative Symptom Schizophrenia Positive-symptom schizophrenia Childhood oddity, irritability, aggressiveness Later age of diagnosis (20-25) Females > Males Better prognosis DA abnormalities – dopamine abnormalities Responds to classical antipsychotic meds Less chance of observable brain damage – less loss of gray matter Negative-symptom schizophrenia versus Childhood withdrawal, passivity Earlier age of diagnosis (16-18) Males > Females Worse prognosis No DA abnormalities Poor response to classical antipsychotic meds 16. Greater chance of observable brain damage – loss of gray matter Two very diff appearances Schizophrenia: The Dopamine (DA) Connection Schizophrenia: The Dopamine (DA) Connection Most powerful hypothesis, things go run in the neurochemistry. Autopsied brains of schizophrenics show high levels of DA. Drugs that increase brain DA can cause disorder that resembles +
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symptom schizophrenia. – if you give drugs and increase of dopamine, ppl will start to develop schizophrenia symptoms, start to develop hallucinations and delusions. Classical medications used to treat + symptom schizophrenia lower brain DA. The neurochemistry like chlopeblah it sits like big flat and prevents dopamine form stimulating the receptor. Individuals treated with those classical medications develop motor signs/symptoms that resemble Parkinson’s disease , which involves the loss of DA neurons. – meds use to treat parkinsos, hype up neurons in basal ganglia that are dying. Too much dopamine makes you look psychotic, too little dopamine makes you loke parkinsonoid. Individuals (10 %) suffering from Parkinson’s disease, when taking medication to restore DA levels, may suffer from a disorder that resembles + symptom schizophrenia. Schizophrenia: Dopamine-Serotonin Interaction Hypothesis Schizophrenia: Dopamine-Serotonin Interaction Hypothesis Classical medications that affect DA control only + symptoms. Newer medications that reduce both DA and serotonin can treat both – and + symptoms. On PET and fMRI scans, reduction of symptoms associated with return of normal brain activity. Schizophrenia: Other Neurochemical Involvement Schizophrenia: Neurokinin 3 (NK3) – movement disorder component Glutamate – NMDA receptor – negative signs / symptoms and cognitive signs Medications affecting each of these neurochemical systems are in varying stages of development.
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