Atenolol, Bisoprolol, Carvedilol, Metoprolol, Nadolol, Propanolol, Timolol CCB Diltiazem, Verapamil Digoxin Anticoagulation: Warfarin DOACs such as Apixiban, Dabigitran, Rivaroxaban, & Edoxaban. Aspirin in low risk cases.
Pharmacological Treatment Rhythm Controllers Sodium Channel Blockers Flecainide (Tambocor) Propafenone (Rhythmol) Quinidine Potassium Channel Blockers Amiodarone Sotalol (Betapace) Dofetilide
Pharmacokinetics Metoprolol (25-100mg PO q12 Hr) Blocks response to beta-adrenergic stimulation. Half life of 3-4 hours. Metabolized by the liver and excreted in the urine. Rivaroxaban (20mg PO Daily) Factor Xa inhibitor. Half life of 5-9hr. Metabolized by oxidative degradation and excreted in the feces. Diltiazem (0.25mg/kg) CCB. Half life of 3-4.5 hrs. Metabolized via hepatic CYP3A4 and excreted in the urine.
Pharmacokinetics Digoxin (3.4-5.1 mcg/kg/day) Inhibits Na-K ATPase. Half life of 1-3 days. Metabolized by the liver and excreted in the urine. Flecainide (50mg PO BID; not to exceed 300mg/day) Class IC; slows conduction in cardiac tissue by altering transport of ion across membranes. Half life of 12-27hrs.
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- Fall '16
- Atrial fibrillation