production and increased suppressor T cells activity genetic factors Mutations

Production and increased suppressor t cells activity

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production and increased suppressor T-cells activity genetic factors ( Mutations in the CARD15 gene) Pathogenesis Lymph node enlarged--------block lymph flow-----oedema, mucosal ulceration (called skipping lesions), abscesses---------- fibrosis/thickening of the bowel wall ----- stenosis of the lumen Serositis develops ------- adherence to other loop --- eventuall y, diseased bowel become: thicker, narrower and shorter
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Signs and symptoms Malaise Pain in the right lower quadrant or generalized abdominal pain and fever chronic diarrhoea results from : bile salt malabsorption, loss of healthy intestinal surface area, and bacterial growth. Stool may be bloody Helpful tests fecal occult test show minute blood in stools small bowel X-ray shows irregular mucosa, ulceration barium enema reveals the string signs (segments of stricture separated by normal bowel), and may show fissures and narrowing of the bowel
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Incidence equal among men and womenHow it happens?
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Progression of ulcerative colitis may lead to intestinal obstruction dehydration electrolytes imbalances malabsorption chronic anaemia Extent and Symptoms Ulcerative proctitis: rectal inflammation and ulceration Proctosigmoiditis: inflammation of rectum & sigmoid colon Left-sided colitis Pancolitis: inflammation of entire colon Fulminant colitis. Recurrent bloody diarrhoea , usually containing pus and mucus, alternating with symptom-free remissions cramping abdominal pain, rectal urgency, and diarrhoea instability, weight loss, weakness, anorexia, nausea
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Diagnosis sigmoidoscopy colonoscopy biopsy barium enema stool specimen analysis
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