ROS have a role in the development of heart disease Alzheimers Disease

Ros have a role in the development of heart disease

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ROS have a role in the development of heart disease, Alzheimer’s Disease, Parkinson’s disease Ethanol metabolized to acetaldehyde in the cytoplasm of the cell. The enzyme alcohol dehydrogenase (ADH) helps with the conversion. During this conversion oxidized niacin (NAD + ) is reduced adverse effects on the liver and causes nutritional disorders. Ethanol is a CNS depressant and therefore acutely depresses motor and intellectual abilities. Acute effects in the liver include pathological effects of chronic ethanol use are seen mainly in the liver and stomach and are thought to be due to the generation of free radicals. Liver failure is the irreversible effect of chronic ethanol
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6 to NADH. In the mitochondria acetaldehyde is further converted by acetaldehyde dehydrogenase to acetate and further oxidized niacin (NAD + ) is reduced to NADH. inflammation, fatty infiltration, hepatomegaly, acute liver necrosis and suppressed fatty acid oxidation abuse. b. Evaluate the process of necrosis, infarct, and apoptosis and describe the implications for clinical practice. Cell Death Cellular Effect Clinical Implications Necrosis cell changes that occur after the cell dies. It is commonly used to describe cell death occurring in the setting of irreversible cellular injury. Tissue shrinkage and sloughing Opaque, white, soap-like lesion Clump resembling cheese Infarct an area of necrosis which results from a sudden insufficiency of arterial blood flow Apoptosis programmed cell death. This is a normal process. It is needed to prevent cellular proliferation that would result in a gigantic body. Can happen in ONE cell Altered Cellular Metabolism 2. Examine the mechanisms and effects of altered cellular metabolism. a. Analyze the steps of ethanol metabolism and describe how it causes hepatocellular damage. b.Analyze the main concepts of ketogenesis and describe the implications for clinical practice.
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3. Examine the basic concepts of cancer nomenclature and biology.
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  • Fall '15
  • david,mary
  • cells

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