What can you conclude from this observation 3

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the skin, there is no difference between the KO and the WT. What can you conclude from this observation? 3. Positive selection markers confer an advantage to an organism, while negative selection eliminates the cell that carries the selected gene. Given what you know about TK, is it possible for TK to ever be used as a positive selection marker? Explain what would happen if the TK gene was placed between the regions of homology. 4. Describe one mouse model for Down Syndrome. How does it differ genetically from the wild type mouse (in what sequences/DNA regions)? 5. A newly identified Chromosome 21 gene, Cholinergin , is suspected in causing degeneration of the basal cholinergic neurons (BFCN) in Down Syndrome patients. The gene is also present on the mouse chromosome Ts65Dn. Suggest one experiment, either in mice or in humans, that will test the hypothesis that Cholinergin contributes to the degeneration of the basal cholinergic neurons (BFCN). A. What type of mice or what type of human patients you will be looking at?
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