Folic acid is a vitamin obtained from yeast leafy

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• Folic acid is a vitamin obtained from yeast, leafy vegetables, and animal liver. Folic acid is reduced within cells to tetrahydrofolate by dihydrofolate reductase .
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Sulfonamide Antibiotics • Bacteria synthesize THF N N H H 2 N HN O N CH 2 -NH- H H H H -C(O)-R H 2 N- -SO 2 -NH 2 Sulfanilamide • Sulfonamide antibiotics, such as sulfanilamide, competitively block the synthesis of THF. • Sulfonamides are not toxic for mammals because they do not synthesize folic acid.
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