MICRO
CNS (1).pptx

The triggerring events for gbs is campylobacter

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. The triggerring events for GBS is: - - Campylobacter jejuni (most common) - Cytomegalovirus - Epstein Barr virus - HIV Other trigering events: - - Immunisation - Surgery - Trauma - Bone marrow transplantation 427
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Historically, the Guillain-Barre syndrome (GBS) was considered a single disorder. . It now is recoginized as a heterogeneous syndrome with several variant forms. The major forms are: - - Acute inflammatory demyelinating polyradiculoneuropathy (AIDP). - The Miller Fisher syndrome (MFS). - Acute motor axonal neuropathy (AMAN) - Acute sensorimotor axonal neuropathy (AMSAN). 428
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Pathogenesis:- Molecular mimicry”. Immune reactions directed against epitopes in Schwann cell surface membrane or myelin cause acute inflammatory demyelinating neuropathy (AIDP). 429
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True about GBS is A/E- (NBE based AI 13 Pattern) a) Demyelination b) Prior viral infection c) Prior bacterial infection d) Predominant sensory involvement D 430
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All of the following statements about Guillain-Barre syndrome are true, except - (NBE/DNB Pattern) a) Inflammatory b) Demyelinating c) Descending d) Cranial nerve involvement C 431
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Which of following is the most common antecedent infection associated with Guillain-Barre syndrome- (NBE/DNB Pattern) a) Mycoplasma b) Epstein-Barr virus c) Chlamydia infection d) Campylobacter jejuni D 432
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All the following are features of Guillain- Barre syndrome except - (AI 96) a) Predominant motor involvement b) Residual disability c) Absence of pleocytosis in CSF d) Sparing of bladder function 433
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Prognosis of the patient with Guillain Barre syndrome:- The clinical course is usually benign and spontaneous recovery begins within 2-3 weeks . Most patients regain full muscular strengh although some are left with residual weakness. The tendon reflexes are the last to recover. . Improvement usually follows a direction, inverse to the direction of involvement with recovery of bulbar functions first and lower extremity weakness resolving last. . Mortality rate is only 5%. Bulbar and respiratory involvement may lead to death if the syndrome is not recognized and treated 434
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C.S.F. findings in Guillain Barre syndrome:- . C.S.F. findings are distinctive in Guillain Barre syndrome There is dissociation between high C.S.F protein and lack of cellular response. “albumino cytological dissociation”. . Elevation in C.S.F. protein without accompanying increase in cells (No pleocytosis). The normal cell count is such a characteristic of GBS that if there is sustained pleocytosis it suggests alternative diagnosis. 435
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436
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All the following are features of Guillain- Barre syndrome except - (AI 96) a) Predominant motor involvement b) Residual disability c) Absence of pleocytosis in CSF d) Sparing of bladder function B 437
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All of the following statements regarding treatment of GBS are true, except – (NBE/DNB Pattern) a) Corticosteroids may be used for early recovery and prevent long hospital stay
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  • Winter '16
  • jean grey

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