for causing vasodilation it increases vascular permeability it increases blood

For causing vasodilation it increases vascular

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for causing vasodilation, it increases vascular permeability, it increases blood flow to the site of injury which ultimately causes erythema and swelling at the site of injury. Cytokines can react quickly or may be more delayed. IL 4 is released early in inflammation and IL13 is released later in the inflammatory response. TNF is released during early and late inflammation. They each have their functions which you can review on the concept map. Leukotrienes are released when the mast cell degranulates. They are also known as slow reaction substances of anaphylaxis (SRS-A) and tend to prolong the inflammatory response. They cause vasodilation and attract neutrophils, monocytes and eosinophils. This is the target of inhibition for the drug singular. Prostaglandins are also released when the mast cell degranulates and are produced by the arachidonic pathway. We will explore this pathway in a different lecture. But
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ultimately, they function to cause vasodilation, platelet aggregation at the site of injury, pain and fever. Monocytes as you can see on the chart have some additional functions that are different from neutrophils and eosinophils. Monocytes become macrophages when
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  • Fall '15
  • david,mary
  • CASCADE, Mast Cell Degranulation

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