secretion sitagliptin vildagliptin Januvia Glavus Onglyza Type 1 or 2 DM DPP 4

Secretion sitagliptin vildagliptin januvia glavus

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secretionsitagliptinvildagliptinJanuviaGlavusOnglyzaType 1 or 2 DM- DPP-4 Inhibitors (a.k.a. gliptins)- Work in GI tract- Increase and prolong action of incretin S.E.: URI, stuffy nose, sore throat, HA,stomach discomfort, diarrhea, hypoglycemia- Administered once a day CATEGORIES OF INSULIN – TYPE 1Time CourseAgentOnsetPeakDurationIndicationsRapid-Actinglispro(Humalog)aspart(Novolog)glulisine(Apidra)10-15 min5-15 min5-15 min1 hour40-50 min30-60 min2-4 hours2-4 hours2 hours- Rapid reduction of glucose level- Clear- Sliding scale insulin- Given w/in 15 min of eating- Most common med Short-Actingregular(Humalog R,½ - 1hour2-3 hours4-6 hours- Regular insulins- Clear
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Novolin R)- Usually administered 20-30 min before a meal- The ONLY insulin approved for IV use- Can be given in pump in type IIntermediate-ActingNPH(Humulin N, Iletin II Lente)2-4 hour3-4 hour4-12 hours16-20hours- Cloudy- Usually taken after food- Eat food around onset and peakVery Long-ActingGlargine(Lantus)Detemir(Levemir)1 hourContinuous (nopeak)24 hours- Used for basal dose- Clear- Cannot be mixed with other insulins - Give 1x a day at the same time Esophageal varices (bleeding)oOcreotide (Sandostatin)oVasopressin (Pitressin) – urgent situationsoBeta-blockers HyperparathyroidismoCorticosteroids (q8-12 hr for 24 hrs followed by low-dose therapy)Contraindications:AscitesoAmmonium chlorideoAcetazolamide (Diamox)HyperparathyroidismoThiazide diuretics – promote the renal absorption of calciumCause hepatitisoIsoniazid (Nydrazid)
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oHalothane (Fluothane)oAcetaminophenoMethyldopa (Aldomet)oCertain antibiotics, antimetabolites, and anesthetic agents Hypothyroidism: thyroid meds can increase effects of:oDigitalis glycosides (digoxin)oAnticoagulant agentsoIndomethacin (Indocin)Cause hypoglycemiaoBBoMAOIoSalicylatesoCoumadinGenericBranUses/IndicationsInformationphenoxybenzamineprazosinterazosindoxazosinDibenzylineMinipressHytrinCardura Pheocromocytoma (Pre-op)- Alpha-adrenergic blocker-10-14 days or longer prior to surgery - S.E.: orthostasis, nasal stuffiness, increasedfatigue, retrograde ejaculation in men
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  • Spring '19
  • Hyperparathyroidism, acute pancreatitis

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