Similarities of thiolase to serine proteases

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Similarities of thiolase to serine proteases: Functionality Serine Protease Thiolase Nucleophile Ser Cys Acyl-enzyme formed yes yes Proton provided by: His (base) unknown base Acyl-enzyme hydrolyzed by: Water CoA S O R1 OH H S O R1 O H S O R1 O H S O R1 O S R2
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4 Energy Yield from Fatty Acid Oxidation See Campbell, 18.3, for the detailed balance sheet (Table18.1) ATP is derived from FADH 2 , NADH, and acetyl-CoA. ATP's produced per six-carbon unit. Glucose: 32 C 6 H 12 O 6 FW = 180 g/mol Fatty acids: 40 C 6 H 12 O 2 FW = 116 g/mol Acyl chains of fatty acids are hydrocarbon whereas carbohydrates are partially oxidized. Additional Topics Odd-numbered fatty acids and the catabolic products of some amino acids result in propionyl-CoA after β -oxidation. Ketone bodies (acetoacetate and acetone) result from the condensation of two acetyl-CoA molecules. Synthesis occurs in the liver. Oxidation occurs normally in other organs. Mitochondrial metabolite transport systems ADP ATP malate malate aspartate acylcarnitine carnitine H + P i pyruvate H + pyruvate H + ketoglutarate α - citrate glutamate Cytosol Matrix 10.25.04
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