Tumor suppressor genes active in normal cells work to

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Tumor suppressor genes, active in normal cells, work to prevent uncontrolled cellgrowth.Proto-oncogenes, which are positive cell-cycle regulators, can becomeoncogenes and cause cancer when mutated.Altered Gene Expression in CancerFree to share, print, make copies and changes. Get yours at ssion-in-cancer-470-11690?campaign_content=book_1514_chapter_16&campaign_term=Biology&utm_campaign=powerpoint&utm_medium=direct&utmProto-oncogenes Can Become OncogenesView on Boundless.comGene Expression > Cancer and Gene Regulation
The DNA in the promoter region of silenced genes in cancer cells is methylatedon cytosine DNA residues in CpG islands.Histone proteins that surround the promoter region of silenced genes lack theacetylation modification that is present when the genes are expressed in normalcells.When the combination of DNA methylation and histone deacetylation occur withincancer cells, the gene present in that chromosomal region is silenced.Epigenetic changes that are altered in cancer can be reversed and may,therefore, be helpful in new drug and therapy design.Epigenetic Alterations in CancerFree to share, print, make copies and changes. Get yours at ons-in-cancer-471-11691?campaign_content=book_1514_chapter_16&campaign_term=Biology&utm_campaign=powerpoint&utm_medium=direct&utm_soEpigenetic Alterations in Cancer CellsView on Boundless.comGene Expression > Cancer and Gene Regulation
The mutations that activate transcription factors can increase the binding of atranscription factor to its binding site in a promoter leading to increasedtranscriptional activation of that gene and resulting in altered cell growth.A mutation in the DNA of a promoter or enhancer region may increase the bindingability of a transcription factor, which may then lead to the increased transcriptionand anomalous gene expression that is seen in cancer cells.Studying how to control the transcriptional activation of gene expression incancer cells along with identifying how a transcription factor binds or a pathwayactivates where a gene can be turned off has led researchers to new drugs andnovel ways of treating cancer.Cancer and Transcriptional ControlFree to share, print, make copies and changes. Get yours at ptional-control-472-11692?campaign_content=book_1514_chapter_16&campaign_term=Biology&utm_campaign=powerpoint&utm_medium=direct&utm_Transcription FactorsView on Boundless.comGene Expression > Cancer and Gene Regulation
Specific cancers have altered expression of miRNAs; changes in the miRNA

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