Copyright 2014 Wolters Kluwer Health Lippincott Williams Wilkins Isoniazid

Copyright 2014 wolters kluwer health lippincott

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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Isoniazid: Interactions Isoniazid: Interactions Interactant drug Effect of interaction Aluminum salts Reduced absorption of isoniazid Anticoagulants Increased risk for bleeding Phenytoin (Dilantin) Increased serum levels of phenytoin Alcohol (in beverages) Higher incidence of drug-related hepatitis
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Pyrazinamide: Adverse Reactions Pyrazinamide: Adverse Reactions Generalized reactions: Nausea and/or vomiting; diarrhea; myalgia; rashes Hepatotoxicity: Symptoms may range from none (except for slightly abnormal hepatic function test results) to a more severe reaction such as jaundice
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Pyrazinamide: Contraindications, Precautions, and Interactions Pyrazinamide: Contraindications, Precautions, and Interactions Contraindicated in patients with known hypersensitivity to the drug; acute gout; severe hepatic damage Use cautiously in patients during pregnancy and lactation; with hepatic and renal impairment; with HIV; with diabetes mellitus Interaction: With allopurinol, colchicine, and/or probenecid—its effectiveness decreases
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Rifampin: Adverse Reactions Rifampin: Adverse Reactions Generalized reactions: Nausea, vomiting Epigastric distress, heartburn, fatigue Vertigo, rash Reddish-orange discoloration of body fluids Hematologic changes, renal insufficiency
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Rifampin: Contraindications, Precautions, and Interactions Rifampin: Contraindications, Precautions, and Interactions Contraindicated in patients with known hypersensitivity to the drug Used cautiously in patients with renal or hearing impairment; during pregnancy and lactation Interactions: With digoxin; oral contraceptives; isoniazid; oral anticoagulants; oral hypoglycemics; chloramphenicol; phenytoin; verapamil
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Copyright © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins Nursing Process: Assessment Nursing Process: Assessment Preadministration assessment: Assess a family history and a history of contacts, if the patient has active TB Ongoing assessment: Observe the patient daily for the appearance of adverse reactions and report if found Carefully monitor vital signs daily
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