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$WFFKPI [GCUV 2QKPV EGPVTQOGTG (KUUKQP [GCUV 4GIKQPCN EGPVTQOGTG *WOCP 4GIKQPCN EGPVTQOGTG *± PWENGQUQOG %'02# PWENGQUQOG *±-µOG³ *³#º< α »UCVGNNKVG TGRGCV D 2QKPV EGPVTQOGTG reviewed in Vardassdonk and Bloom 2011 Guse et al 2011 Nature 477: 354-358 Ectopic locallization of CenpC to DNA induces kinetochore assembly Gascoigne et al 2011 Cell 145: 410-422 Centromeres
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SUR RanGAP CLASP CLIP170 ch-TOG Mtw1/ MIS12 complex Ndc80/ HEC1 complex Spc105/ KNL1 Mcm21 complex CENP-K CENP-Q CENP-P CENP-L CENP-R CENP-I CENP-O CENP-S CENP-M CENP-H CENP-C CENP-T CENP-N CENP- U50 Inner kinetochore Outer kinetochore PLK1 ZWINT EB1 CDC20 CDC20 CDC20 CDC20 CDC20 APC/C BUB3 BUBR1 CENP-E BUB3 BUB1 CENP-F Corona C C RZZ NPC LIS1 Dynein– dynactin MPS1 CRM1 RanBP2 O O O O O O Soluble O-MAD2 kMTs Soluble CDC20 +TIPs MAD1– C-MAD2 AurB INCENP BOR AurB INCENP BOR MCAK MCAK Centromere CENP-A nucleosomes + + + – – – SUR Kinetochore A linker that allows the attachment of microtubules to chromosomes * how to move chromosomes * how to attach microtubules * sensing attachment Reviews: Cheeseman and Desai, 2008, Nat. Rev. Mol. Cell Biol.
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