A new host by physical contact biological

a new host by physical contact. Biological transmission occurs when the arthropod carries the viral pathogen
inside its body and transmits it to the new host through biting.
In humans, a wide variety of viruses are capable of causing various infections and diseases. Some of the
deadliest emerging pathogens in humans are viruses, yet we have few treatments or drugs to deal with viral
infections, making them difjcult to eradicate.
Viruses that can be transmitted from an animal host to a human host can cause zoonoses. For example, the
avian inkuenza virus originates in birds, but can cause disease in humans. Reverse zoonoses are caused by
infection of an animal by a virus that originated in a human.
MICRO CONNECTIONS
Fighting Bacteria with Viruses
The emergence of superbugs, or multidrug resistant bacteria, has become a major challenge for
pharmaceutical companies and a serious health-care problem. According to a 2013 report by the US Centers
for Disease Control and Prevention (CDC), more than 2 million people are infected with drug-resistant bacteria
in the US annually, resulting in at least 23,000 deaths.
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The continued use and overuse of antibiotics will likely
lead to the evolution of even more drug-resistant strains.
One potential solution is the use of phage therapy, a procedure that uses bacteria-killing viruses
(bacteriophages) to treat bacterial infections. Phage therapy is not a new idea. The discovery of bacteriophages
dates back to the early 20th century, and phage therapy was jrst used in Europe in 1915 by the English
bacteriologist Frederick Twort.
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However, the subsequent discovery of penicillin and other antibiotics led to
the near abandonment of this form of therapy, except in the former Soviet Union and a few countries in
Eastern Europe. Interest in phage therapy outside of the countries of the former Soviet Union is only recently
re-emerging because of the rise in antibiotic-resistant bacteria.
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Phage therapy has some advantages over antibiotics in that phages kill only one specijc bacterium, whereas
antibiotics kill not only the pathogen but also benejcial bacteria of the normal microbiota. Development of
new antibiotics is also expensive for drug companies and for patients, especially for those who live in countries
with high poverty rates.
Phages have also been used to prevent food spoilage. In 2006, the US Food and Drug Administration approved
the use of a solution containing six bacteriophages that can be sprayed on lunch meats such as bologna, ham,
and turkey to kill Listeria monocytogenes , a bacterium responsible for listeriosis, a form of food poisoning.
Some consumers have concerns about the use of phages on foods, however, especially given the rising
popularity of organic products. Foods that have been treated with phages must declare “bacteriophage
preparation” in the list of ingredients or include a label declaring that the meat has been “treated with
antimicrobial solution to reduce microorganisms.”
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CHECK YOUR UNDERSTANDING
• Why do humans not have to be concerned about the presence of bacteriophages in their food?