7 22 source unaids 2008 global report according to

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7 2.2 Source : UNAIDS 2008 global report According to Worldwatch Institute South Africa’s HIV epidemic is worst in the world 1 of every 5 adults will die of AIDS over the next 10 years
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8 Graduate student took this in Tanzania
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9 Lecture 9 • Replication of HIV • Apoptosis • Syncytia formation • HIV genome and genes • HIV mutations • Time course of HIV infections 5/2/2013
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10 Steps in general viral replication 1. Union of virus and host cell (adsorption) 2. Penetration and uncoating 3. Nucleic acid synthesis 4. Viral protein synthesis 5. Assembly of new viruses 6. Release of new viruses Capsid Genome Nucleus Genome Capsid Fig 2.13
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12 Life cycle of HIV
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13 Provirus = lysogeny = latent infection
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14 Movie of HIV replication cycle
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15 HIV life cycle. mov
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16 Replication Cycle of HIV reverse transcriptase Replicating host cells Virus is ready to “bud” out of infected cell provirus (a) (f) (e) (d) (c) (b) HIV RNA RNA provirus host DNA cell nucleus capsid provirus New viral capsids and RNA host DNA cell nucleus New spikes inserted in cell membrane reverse transcriptase host DNA HIV DNA Latent infection e. Active replication Budding +\- lysis or lytic infection
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17 Lytic vs Lysogenic Cycle of Bacteriophage
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18 Virus Lysogenic & Lytic Cycle
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19 Latent infection/Lysogeny • Normally Lysogeny is the same thing as a latent infection; the virus exists as a provirus in the
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  • Winter '08
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