Question 19 of 22 40 points consider 3 different

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Question 19 of 22 4.0 Points Consider 3 different nucleotide analog drugs (that work similarly to AZT) : Drug X: reduces viral replication rate 10 fold , requires 2 amino acid changes for resistance to evolve, and once resistance evolves, reverse transcriptase continues to make mistakes at the same rate as before the evolution of drug resistance. Drug Y: reduces viral replication rate 100 fold , requires 3 amino acid changes for resistance to evolve, and once resistance evolves, as a by-product of this resistance, reverse transcriptase is 10-fold more error prone . Drug Z: reduces viral replication rate 100 fold , requires 3 amino acid changes for resistance to evolve, and once resistance evolves, as a by-product of this resistance, reverse transcriptase is 10-fold less error prone . If you were to give ONE of these drugs in combination with AZT, which would be the best one to give and why? Pick the ONE BEST choice: A. Drug X, because it only reduces viral replication by 10 fold, so therefore there will be a lot of viral progeny with different mutations showing up, helping to eliminate HIV in the long-run. B. Drug X, because it requires 2 amino acid changes for resistance to evolve instead of 3 amino acid changes for Y and Z. C. Either Y or Z would be equally effective in combination with AZT because both drugs reduce viral replication equally well and require the same number of amino acid changes for resistance to evolve. D. Drug Y, because if reverse transcriptase is more error prone after resistance has evolved, Drug Y will help to speed up the generation of mistakes by HIV, resulting in elimination of the virus. E. Drug Z, because if reverse transcriptase is less error prone after resistance has evolved, it will be harder to generate resistance against the second drug (AZT). Reset Selection Mark for Review What's This? Question 20 of 22 4.0 Points You discover two new viruses, virus A and virus B, that both infect birds and cause the same disease but through two different mechanisms. Virus A only produces a small number of virions, while virus B produces a greater number of virions. You apply a drug that targets virus A and virus B equally, and notice that the efficacy of this drug for killing virus A quickly drops, while the drug remains effective for killing virus B during this time. Which one(s) of the following choices could explain the different potencies of this drug for virus A and virus B? Pick ALL that apply: A. Virus A has a longer generation time than virus B. B. Virus A has a greater mutation rate than that of virus B. C. Some birds have been co-infected with both virus A and virus B. D. The population of virus A has greater genetic diversity than that of virus B. E. Virus A is not in Hardy-Weinberg Equilibrium, while virus B remains in Hardy-Weinberg Equilibrium. F. none of these Mark for Review What's This?
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