Lecture 9 - Recognition -Immune System-1

Foreign parasites while ignoring the hosts cells and

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foreign parasites while ignoring the host’s cells and proteins Recognizes foreign molecules = Antigen B cells release Immunoglobulins to circulation T cells have T cell Receptor that recognizes when presented on MHC class 1 protein
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Antibodies: Immunoglobulin G Composed of two heavy chains and two light chains Composed of constant domains and variable domains Light chains: one constant and one variable domain Heavy chains: three constant and one variable domain Variable domains of each chain make up antigen binding site (two/antibody) Variable domains contain regions that are hypervariable (specificallythe antigen binding site) Confers high antigen specificity
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Antibodies: Immunoglobulin G
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Antibodies: Immunoglobulin G
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Immunoglobulin Molecule - IgG • Heterotetramer 2 Light chains +2 Heavy chains Linked by 4 disulfide bonds Hinge region of HC gives flexibilbity Ig fold is distorted barrel Each LC contains 2 Ig folds Each HC contains 4 Ig folds Distored conformation stabilized by intrachain disulfide bridges Antigen recognition at loops between strands at N-terminus of Ig
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