prior to next dose Abrupt withdrawal causes life threatening MI Ventricular

Prior to next dose abrupt withdrawal causes life

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prior to next dose Abrupt withdrawal causes life threatening MI, Ventricular arrhythmia, death Consult before take OTCs for cold remedies
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Cholinergic Agents : aka parasympathomimetics or muscarinic agonists promote or mimic the action of acetylcholine (ACh) Main uses: Decrease intraocular pressure in glaucoma Treat atony of gastrointestinal tract & urinary bladder Diagnose or treat myasthenia gravis Physostigmine—used to treat anticholinergic toxicity (atropine) Direct-acting cholinergic (nonspecific) Indirect acting cholinergic (Indirect acting cholinesterase inhibitors) reversible Prototyp e Bethanechol (Urecholine) Pilocarpine (Pilocar) Neostigmine bromide (prostigmin) Increase tone of detrusor bladder constrictions Increase gastric tone Constrict pupils, acute glaucoma ADRs Contraindication in peptic ulcer; intestinal obstruction; urinary tract obstruction; bronchospasm; pre- existing hypotension, bradycardia, cardio dz; hyperthyroidism More common with S.C administration GI Sx: abd pain, nausea, belching, diarrhea Uterine irritability, muscular weakness in neonate, No combination with succinylcholine & aminoglycoside Toxicity (Muscarinic poisoning): abd cramps, salivation, flushing, n/v antidote: atropine Clinical use Urinary retention d/t neurogenic atony of To Treat Myasthenia Gravis: Neostigmine & Pyridostigmine
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bladder Not used for reflux Alzheimer’s dz: Donepezil (Aricept) Educati on Take 1hr before or 2 hrs after meal (starts at 5- 10mg and repeat every hour until satisfactory response ) No IV or IM severe toxicity (bloody diarrhea, bradycardia, profound hypotension, cardiovascular collapse) Notify when developing abd discomfort, salivation, sweating or flushing to reduce or discontinue drugs Orthostatic hypotension: no exercise in hot weather, drink noncaffeinated liquids Anticholinergics : aka cholinergic blockers, muscarinic antagonists Prototype: Atropine Belladonna tincture: Trihexyphenidyl (Artane)& Benztropine (Cogentin)-parkinson, Oxybutynin Cl (Ditropan)-overactive bladder, Scopolamine (Hycosine)-prevention Motion sickness or post-op N/V, Main use: Block vagal impulses to heart. Suppress or decrease Respiratory secretions (pre-op medication) Bladder spasms Relax sphincter muscle of iris.\ Treat tremors/rigidity of Parkinsonism. Treat side effects of psychotropic medications.
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  • Spring '14
  • Henrikson,J
  • Bradycardia

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